396 Mucosal Healing and Mortality in Celiac Disease

Mucosal healing and mortality in coeliac disease.

BACKGROUND Coeliac disease (CD), characterised by the presence of villous atrophy (VA) in the small intestine, is associated with increased mortality, but it is unknown if mortality is influenced by mucosal recovery. AIMS To determine whether persistent VA is associated with mortality in CD. METHODS Through biopsy reports from all pathology departments (n = 28) in Sweden, we identified 7648...

Mucosal Recovery and Mucosal Healing in Biopsy-Defined Adult Celiac Disease

Celiac disease (gluten-sensitive enteropathy) is an immune mediated disorder with characteristic histopathological small bowel mucosal changes that respond to a strict gluten-free diet. Recent studies have suggested that complete (rather than partial) mucosal recovery and healing is possible, but in some this may require a more prolonged period than is currently appreciated. In this study, 182 ...

Mucosal healing in patients with celiac disease and outcomes of pregnancy: a nationwide population-based study.

BACKGROUND & AIMS Studies have associated undiagnosed celiac disease with adverse outcomes of pregnancy. We investigated the association between persistent villous atrophy and outcomes of pregnancy in women with celiac disease. METHODS We collected data on 337 women with celiac disease who gave birth (to 460 infants) within 5 years of a follow-up biopsy, from 28 pathology departments in Swede...

Mucosal Expression of Claudins in Celiac Disease

Mucosal tissue transglutaminase expression in celiac disease

Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies to tTG are a diagnostic marker of gluten-sensitive enteropathy. The aim of this study was to investigate the localization of tTG in the duodenal mucosa in control tissues and in different histological stages of celiac disease by using a commercial and a novel set of anti-tTG monoclonal antibodies...